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University Hospitals Health System (UHHS) is on a mission to teach, research, and administer good health throughout Northeast Ohio. Its flagship facility University Hospitals of Cleveland (UHC), which operates as University Hospitals Case Medical Center (UHCMC), is a 1,000-bed tertiary care center serving Cleveland and other parts of northeastern Ohio. The teaching hospital, which is affiliated with Case Western Reserve University, is also home to Rainbow Babies & Children's Hospital, Ireland Cancer Center, and MacDonald Women's Hospital. Founded in 1866, the not-for-profit UHHS is also home to community hospitals, outpatient health and surgery centers, mental health facilities, and pediatric specialty centers.

University Medical Center of Southern Nevada is an affiliate of the University of Nevada School of Medicine. The medical center includes a teaching hospital and a network of community and urgent care health centers. Among its specialized services are cancer treatment, heart care, pediatrics, and rehabilitation. It also offers birthing, wound and burn care, neurological disorder, and Level 1 trauma centers. University Medical Center serves southern Nevada along with parts of Arizona, California, and Utah. The medical center opened its doors in 1931 with 20 beds.

University of Colorado Hospital Authority won't pull you over for driving too fast, but it might pull you over for mistreating your body. The Denver-based organization includes the University of Colorado Hospital, which is a teaching institution for, you guessed it, the University of Colorado. Its Anschutz Inpatient Pavilion in Aurora is a 400-bed community hospital. The health care system also operates a number of specialty care facilities, including the Anschutz Cancer Pavilion, which not only offers cancer treatment but also conducts research, and the Rocky Mountain Lions Eye Institute. Half a dozen clinics in and around Denver offer primary care.

University of Connecticut Health Center includes a full-service acute care medical center, the 225-bed John Dempsey Hospital, which conducts medical treatment, educational training, and clinical research. The hospital facility provides specialty care including cardiovascular, cancer, neurological, behavioral health, emergency, and ambulatory services, among others. The University of Connecticut Health Center was founded in 1961.

University of Iowa Hospitals and Clinics partners with the University of Iowa Roy J. and Lucille A. Carver College of Medicine and the University of Iowa Physicians group practice organization to make up the University of Iowa Health Care network. The organization provides residents of the Hawkeye State with an acute care hospital serving a variety of inpatient and outpatient needs, including more than 200 health care specialties. The facility also houses the Children's Hospital of Iowa and the Holden Comprehensive Cancer Center. As an teaching facility, it also houses 20 academic departments. The health care system, founded in 1898, has some 680 beds.

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