Orpea owns and operates facilities scattered all over the country. Chairman and CEO Jean-Claude Marian owns a little over a third of Orpea. No, you're not having a senior moment. Orpea -- not Opera -- is one of France's leading providers of long-term care to the elderly or infirm. Orpea started out running facilities that included retirement homes and assisted-living residences, which are still operated under the Orpea name, but it has branched out to also provide care in physical therapy and psychiatric clinics, which operate through the company's Clinea subsidiary.

Blue Cross and Blue Shield of Massachusetts (BCBSMA) covers some 3 million members. The company, an independent licensee of the Blue Cross and Blue Shield Association, offers a variety of individual and employer-sponsored health care plans, including HMO (HMO Blue), PPO (Preferred Blue), and point-of-service (Blue Choice) plans, as well as various hybrid options and personal spending accounts to cover out-of-pocket costs. BCBSMA also provides Medicare options and dental, vision, and prescription drug coverage. The health care firm was founded in 1937.

Denver Health and Hospital Authority provides residents of the Mile High City with a variety of health care services. The medical system's primary facility is the Denver Health Medical Center, a 475-bed hospital that functions as a regional trauma center. It also includes a network of neighborhood, school-based, and specialty health clinics, a poison and drug center, a medical health plan, and a 911 response system for Denver County. Denver Health has research and educational operations, and it houses the Rocky Mountain Center for Medical Response to Terrorism, Mass Casualties and Epidemics, as well as the Colorado Biological, Nuclear, Incendiary, Chemical and Explosive (BNICE) Training Center.

AmeriHealth Mercy Health Plan provides Medicaid health insurance plans to more than 100,000 recipients in 15 Central and Northeastern Pennsylvania counties. It provides managed care services including medical, dental, vision, prescription, and special needs. The company was founded with 300 members in 1982 as the Mercy Health Plan at Philadelphia's Misericordia Hospital. AmeriHealth Mercy Health Plan is part of the AmeriHealth Mercy family of companies, which includes the Keystone Mercy Health Plan, University Health Care, and PerformRx, and is a partnership between Mercy Health System and AmeriHealth.

AorTech develops and manufactures medical-grade polyurethanes for use in medical devices and implants. Its products are based on the company's Elast-Eon materials which have various applications including in drug-eluting stents, in orthopedic devices (spinal discs), and for reconstructive/cosmetic uses (breast implants). The company's wholly-owned subsidiary, AorTech Biomaterials, based in Melbourne, Australia, was formed more than a decade ago to commercialize the company's range of medical-grade polyurethanes. Bluehone Investors (chaired by AorTech director Stuart Rollason) holds about 20% of the company's shares.

UCI Medical Affiliates seeks out doctors looking to avoid paperwork.UCI Medical Affiliates company provides practice management services to about 60 freestanding medical clinics, mostly in South Carolina. (It has one center in Tennessee.) The clinics operate primarily under the Doctors Care and Progressive Physical Therapy names. UCI provides nonmedical management and administrative services, such as planning, accounting, insurance contracting and billing, non-medical staffing, and other office services. Its Doctors Care locations are urgent care clinics that handle minor emergencies and provide primary care services. Blue Cross and Blue Shield of South Carolina is the company's principal stockholder.

Nipro Diagnostics,Inc. makes blood glucose monitoring systems and disposable supplies for diabetics, which it sells through retail pharmacies, mass merchandisers, managed care companies, mail service providers, and distributors around the globe. Nipro Diagnostics markets its testing systems and blood monitors through those distribution channels in two ways, under its own brand names -- including Sidekick, TrueTrack Smart System, TRUEread, and Prestige IQ -- and through co-branded partnerships. The company is a wholly owned subsidiary of Japanese medical device maker Nipro.

Brooks Health System operates Brooks Rehabilitation Hospital, a more than 140-bed facility dedicated to helping patients recover from injury and illness. Rehabilitation services include physical, occupational, and speech therapy. The not-for-profit hospital also helps patients coping with chronic pain, cognitive disorders, and other long-term disabilities. Brooks Health System provides outpatient care through a network of some two dozen outpatient clinics in northeast Florida. The system is a research affiliate of the Health Science Center at the University of Florida.

Most syringes are designed to inject medication into blood vessels, but Mercator MedSystems' (formerly EndoBionics) MicroSyringe is designed to go inside blood vessels and inject medication outside the vessel wall, allowing for a more targeted application of medication that reduces the amount dispersed to areas where it is not needed. In addition to delivering traditional injectable drugs, it can deliver stem cells and gene therapies. The MicroSyringe, which was approved for use by the FDA in 2004, can be used to treat tumors and vascular, cardiac, and neurological diseases.

DTI specializes in cosmetic and restorative dentistry products such as dentures, crowns, bridges, and dental implants. DTI Dental provides dental laboratory services through about a dozen dental labs in the US and four in Canada. The company has shifted focus toward making more use of digital technology in recent years and to that end the company has partnered up with BioHorizons, which provides a host of digital dentistry services such as computer aided design of crowns and abutments and computer aided manufacturing. Both companies, DTI Dental and BioHorizons are owned by private equity firm Healthpoint Capital.

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