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The German drug company -- seller of popular over-the-counter remedies Zantac and Dulcolax, as well as prescription Flomax for enlarged prostate -- makes a host of prescription and OTC products, not to mention fine chemicals and pet medications. Its prescription drugs include treatments for respiratory ailments, hypertension, HIV, and depression. Boehringer also offers cold, gastrointestinal, and pain remedies, as well as vaccines, drugs, and nutritionals for farm animals and pets. The company operates worldwide. The founding Boehringer family controls the company through parent company C.H. Boehringer Sohn.

Boehringer Ingelheim Pharmaceuticals brings a little German drugmaking know-how to the USA. The firm is the pharmaceuticals unit of Boehringer Ingelheim Corporation, which is the US headquarters of Germany's Boehringer Ingelheim. It sells a range of prescription and over-the-counter drugs in the US market, including respiratory treatments Spiriva and Atrovent; high blood pressure medication Micardis; enlarged prostate treatment Flomax; Parkinson's disease drug Mirapex; and HIV/AIDS products Aptivus and Viramune. It is also an R&D center for Boehringer Ingelheim, specializing in immunology, inflammatory conditions, and cardiovascular disease.

Bristol-Myers Squibb Company was founded in 1887 and is headquartered in New York, New York. Bristol-Myers Squibb Company, a global biopharmaceutical company, engages in discovering, developing, and delivering medicines that help patients prevail over serious diseases. The company focuses on the areas of serious unmet medical need, such as cardiovascular disease, mental illness, cancer, HIV/AIDS, hepatitis B and C, rheumatoid arthritis, type 2 diabetes, solid organ transplantation, and Alzheimer's disease. Its lead products include cardiovascular medicines, including PLAVIX and AVAPRO/AVALIDE; ABILIFY, a medicine for the treatment of mental illness; ERBITUX, SPRYCEL, and IXEMPRA, which are cancer medicines; HIV medicines, such as REYATAZ, SUSTIVA, and ATRIPLA; BARACLUDE, a medicine for hepatitis B; ONGLYZA, a type 2 diabetes treatment; and ORENCIA, a medicine for rheumatoid arthritis. The company also has a pipeline with compounds in phase III clinical trials, including apixaban, dapagliflozin, ipilimumab, belatacept, and brivanib. It sells its products to wholesalers, distributors, retailers, hospitals, clinics, government agencies, and pharmacies. Bristol-Myers Squibb Company has agreements with Sanofi-Aventis; Otsuka Pharmaceutical Co., Ltd.; Eli Lilly and Company; Gilead Sciences, Inc.; AstraZeneca PLC; Pfizer, Inc.; and various biotech companies.

Callisto Pharmaceuticals, Inc. was founded in 1996 and is headquartered in New York, New York. Callisto Pharmaceuticals, Inc., a development stage biopharmaceutical company, focuses primarily on the development of drugs to treat gastrointestinal disorders and diseases, rheumatoid arthritis, neuroendocrine cancer, and acute leukemia. The company has three drugs in development, which include SP-304, a guanylyl cyclase C receptor agonist for the treatment of chronic constipation and constipation-predominant irritable bowel syndrome, which has completed Phase I clinical trial; Atiprimod, an orally administered drug with antiproliferative, anti-inflammatory and antiangiogenic activities, which is in Phase II development for advanced carcinoid cancer; and L-Annamycin, a novel compound from the anthracycline family of proven anti-cancer drugs for the treatment of leukemia. It also focuses on the development of Atiprimod for the treatment of rheumatoid arthritis. The company has license agreements with AnorMED Inc. to research, develop, sell, and commercialize the Atiprimod patent rights; and the University of Texas M.D. Anderson Cancer Center to develop and commercialize the L-Annamycin patent rights.

Cambridge Laboratories Limited company was founded in 1987 and is now owned by its board of directors. Cambridge Laboratories develops and distributes pharmaceuticals to treat the central nervous system, cancer, vitamin deficiency, and other niches. Its product line includes ImmuCyst (for treatment of superficial bladder cancer), Nabilone (chemotherapy-related nausea and vomiting), and Gelclair (oral ulcers and inflammation). Cambridge Labs has distribution alliances to market its products in over 40 countries.

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