Perlegen deciphers genetic signatures. The biotech research company performs whole genome scans to help drugmakers improve drug safety and efficacy and optimize clinical trials. The company also researches the genetic causes of disease and drug response. Using DNA probe arrays from Affymetrix, which owns some 20% of the firm, Perlegen examines multiple whole genomes at a time, looking for variations (single nucleotide polymorphisms, or SNPs) that are responsible for disease. SNPs and groups of SNPs, known as haplotypes, are also responsible for the response, or lack of one, to a drug. Drugmakers hope to use this information to develop genetically targeted medicines.

Clinimetrics Research Associates, Inc. company is a contract research organization (CRO) that provides clinical research services, consulting, project management, data management, and electronic data capture services through most stages of clinical trials. Its services aim to control costs for customers including global biotechnology, pharmaceutical, and medical device companies. It specializes in biotech development, as well as in therapeutic areas such as oncology and cardiology research. Clinimetrics has locations throughout North America. The company is a subsidiary of institutional pharmacy operator Omnicare.

The Whitehead Institute for Biomedical Research blazes new trails in bioscience. The organization, funded by both the public and private sectors, investigates such diseases as Parkinson's and cancer and dives into the depths of biology, genomics, and genetics to gain new understanding about disease and health. The Whitehead Institute contributed to the international effort to map the human genome, and is actively researching stem cells. Other achievements include discovering a system for multiplying adult stem cells and creating the first genetically defined human cancer cell. The institute was founded in 1982 by philanthropist Edwin "Jack" Whitehead and draws researchers from MIT.

TECHNE Corporation was founded in 1976 and is headquartered in Minneapolis, Minnesota. TECHNE Corporation, along with its subsidiaries, is engaged in the development, manufacture, and sale of biotechnology products and hematology calibrators and controls. The Company’s activities are conducted, through its wholly owned subsidiaries, Research and Diagnostic Systems, Inc. (R&D Systems), and BiosPacific, Inc. (BioPacific). The Company distributes the biotechnology products in Europe, through its wholly owned United Kingdom-based subsidiary, R&D Systems Europe Ltd. (R&D Europe). The Company distributes biotechnology products in the People’s Republic of China, through its wholly owned subsidiary, R&D Systems China, Co. Ltd. (R&D China). The Company operates in three business segments: biotechnology, R&D Europe and hematology.

Microbix makes biotherapeutic drugs, vaccines, and infectious disease diagnostics for multinational manufacturers. The company's pipeline includes leading generic drug candidate ThromboClear for the treatment of coronary artery thrombosis and the FDA-approved drug urokinase, used to treat pulmonary embolism. Microbix has also submitted patents for its Sperm Sexing Technology, which enables livestock producers to predetermine offspring gender prior to conception. In 2008 Microbix entered into an agreement with China to build one of the world's largest influenza manufacturing plants to produce flu vaccines.

Greer Laboratories, Inc. company develops and manufactures a variety of allergy immunotherapy testing and treatment materials. Greer operates through four business units: Human; Veterinary; Source Materials; and Contract Development. Greer Laboratories company's products include allergenic extracts, vials, single and multiple skin testing devices, and safety syringes, as well as source materials used for allergy testing such as dust mites, venoms, dander, molds, insects, and pollen. Greer Laboratories company began operations in 1904.

Metabolic Nutrition ships out products that help people shape up. Products include meal replacement shake powders, weight loss supplements, and anti-oxidant formulations. Its weight loss division offers products such as SyneDrex and Phenolox, which are metabolism stimulators, and Ametrol, a carbohydrate inhibitor. Sports performance offerings includes meal replacement Advantage and stamina enhancer TAG. The health and wellness division offers customers vitamin supplement Quidprim and immune system booster Stipatore, among other formulations. Metabolic Nutrition's products are sold in select health food stores; the company also takes orders through its Web site and over the phone.

GTC Biotherapeutics develops, produces, and commercializes therapeutic proteins through transgenic animal technology. ATryn®, our recombinant form of human antithrombin, is the first transgenically produced protein to be approved anywhere in the world, having recently been approved by the European Commission for the prophylactic treatment of deep vein thrombosis in patients with hereditary antithrombin deficiencies that are undergoing surgical procedures. ATryn® is produced in the milk of goats developed using micro-injection technology to incorporate a human antithrombin transgene. In addition to ATryn®, GTC is developing additional recombinant forms of therapeutic proteins normally found in human blood plasma as well as monoclonal antibodies. These products have potential applications in hematology, oncology, and autoimmune diseases.

4Life Research wants to protect the health of bipeds and quadrupeds alike. The multilevel marketing company manufactures nutritional supplements for humans and animals and sells them through its global network of independent distributors. The company's flagship product is Transfer Factor, a supplement made from egg yolks and cow colostrum that is meant to enhance the body's immune system. The firm makes Transfer Factor formulations for humans, dogs, cats, horses, and livestock. The privately-held company was founded in 1998 by CEO David Lisonbee, who had previous experience with multi-level marketing organizations.

Pharmos Corporation was founded in 1990 and is headquartered in Iselin, New Jersey. Pharmos Corporation, a biopharmaceutical company, engages in the discovery and development of novel therapeutic drugs to treat a range of diseases of the nervous system in the United States and Israel. It focuses on the diseases of the nervous system, such as the disorders of the brain-gut axis, pain/inflammation, and autoimmune disorders. Pharmos's lead product candidate includes dextofisopam, a non-serotonergic agent, which is in Phase IIb clinical trials for the treatment of irritable bowel syndrome (IBS). Its product pipeline also includes VPI-013 that completed Phase IIa testing for the treatment of female sexual dysfunction and neuropathic pain; CB2-selective cannabinoids for the treatment of inflammatory/autoimmune diseases; and Tianeptine, which is in Phase I clinical trials for the treatment of IBS and functional dyspepsia. In addition, Pharmos Corporation's products under development comprise Cannabinor that has completed two Phase IIa proof of principle trials for treating pain; and NanoEmulsion drug delivery system, which is in Phase IIa clinical trial for the treatment of knee osteoarthritis. Pharmos's therapeutic drugs are also used to treat autoimmune disorders.

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