Kyorin, founded in 1923, already has affiliates and subsidiaries in Germany and the US. KYORIN Co., Ltd. is a Japan-based holding company engaged in the manufacture and sale of pharmaceuticals. The Company operates in two business segments. The Pharmaceuticals segment is engaged in the manufacture, purchase and sale of pharmaceutical products, the evaluation of technologies, the inspection, analysis and negotiation of license affiliations, the manufacture of clinical testing products, as well as the research of new drugs and candidate compounds. The Others segment is involved in the development and sale of cosmetics, as well as raw materials of medicines and cosmetics, the promotion of sales, the planning and production of advertisements, the sale of packaging materials, in addition to the provision of advisory services and the operational management of funds.

Agennix develops oral, topical, and other forms of cancer treatments. The company's primary candidate, Talactoferrin, is an oral therapy in the late stages of development that is targeted to treat non-small cell lung cancer, a common and slow-growing type of lung cancer. Its other clinical development-stage candidates include therapies to treat tumors and prostate cancer, as well as non-cancerous conditions such as sepsis and diabetic foot ulcers. Agennix, which has offices in Munich, Germany; Princeton, New Jersey; and Houston, Texas, was formed in 2009 from the merger of Germany-based GPC Biotech AG and US-based Agennix Inc.

Vaxon Biotech is a biopharmaceutical company focused on the treatment of cancers and related malignancies. Disease targets include breast, lung, pancreatic, and prostate cancer. The company's claim to fame is its development of optimized cryptic peptide antigens (substances that trigger protein responses in the immune system), which have shown early progress in the immune response against these cancers. The company's development products are classified as therapeutic vaccines and are developed to trigger the immune system to attack malignant cells in solid tumors while steering clear from normal cells.

Isotechnika Pharma may have isolated a new drug to combat organ rejection. Lead drug candidate voclosporin could replace cyclosporine as the immunosuppressant of choice for organ transplant recipients and patients with autoimmune conditions. Studies indicate it is more effective and has fewer side effects than cyclosporine. Isotechnika is testing the drug for kidney transplant recipients and psoriasis. Minority shareholder Paladin Labs has signed on to develop and market the drug in certain markets. Its Isotechnika Diagnostics division sells "breathalyzer" tests to diagnose H. pylori infections, which cause chronic gastritis and ulcers.

AVI BioPharma, Inc. was founded in 1980 and is based in Corvallis, Oregon. AVI BioPharma, Inc., a biopharmaceutical company, engages in the discovery and development of therapeutic products based on antisense and cancer immunotherapy technology. The company's products under various development stages comprise AVI-4658, a Phase I human clinical trial product to restore, prevent, or slow deterioration of muscle function; AVI-5038, a preclinical stage product to skip exon 50 and restore a range of associated mutations; AVI-5126, a Phase II clinical trial product for the treatment of cardiovascular restenosis; and AVI-6002 and AVI6003, which are in Phase I clinical trials to treat diseases caused by Dengue, Ebola, Marburg, and Junín viruses. It has strategic alliances with Chiron Corporation; Cook Group Incorporated; Ercole Biotech, Inc.; Eleos Inc.; Charley's Fund, Inc.; and the United States Department of Defense.

MannKind Corporation was founded in 1991 and is headquartered in Valencia, California. MannKind Corporation, a biopharmaceutical company, focuses on the discovery, development, and commercialization of therapeutic products for diseases, such as diabetes and cancer. Its lead product candidate, AFRESA, a rapid-acting insulin that has completed phase 3 clinical trials for the treatment of diabetes in the United States, Europe, and Japan. The company's lead product candidates also include MKC1106-PP, which is in phase I clinical trial for the treatment of various solid-tumor cancers, including ovarian, colorectal, pancreatic, renal, breast, non-small cell lung and prostate carcinomas, glioblastoma, and melanoma.

ZARS Pharma, Inc. operates as a specialty pharmaceutical company that focuses on developing and commercializing topically administered drugs using its proprietary drug delivery technologies, primarily in the area of pain management. It is developing a portfolio of proprietary products and product candidates based on its Controlled Heat-Assisted Drug Delivery and phase-changing cream technologies. The company’s products include Pliaglis, a topical anesthetic cream for dermal anesthesia prior to painful cosmetic procedures, such as laser surgery and dermal filler injections; and Synera, a topical patch for providing dermal analgesia for potentially painful superficial procedures, such as venous access procedures involving needles and immunization injections of children. Its products also comprise ThermoProfen, which is entering into Phase 3 clinical trials for the treatment of mild to moderate chronic pain associated with osteoarthritis of the knee; and Ketoprofen DuraPeel, a Phase 1 clinical trial product for the treatment of acute musculoskeletal pain resulting from soft tissue injuries, such as muscle strains, ankle sprains, and sports injuries. In addition, the company is developing the Alprazolam Patch, which is in Phase 1 clinical trial, for the treatment of panic disorder. The company was formerly known as ZARS, Inc. and changed its name to ZARS Pharma, Inc. in July, 2007. The company was founded in 1996 and is based in Salt Lake City, Utah.

Pacific Biosciences, Inc. company was founded in 2004 and is based in Menlo Park, California. Pacific Biosciences, Inc. operates as a biotechnology company in North America. The company develops a transformative single-molecule (SMRT) DNA sequencing platform, which enables the observation of natural DNA synthesis by a DNA polymerase as it occurs; simplifies the resequencing of complex genomes; and the characterization of structural variation, including insertions, deletions, and rearrangements. Its products include SMRT chip, which enables the observation of individual fluorophores against a dense background of labeled nucleotides by maintaining a signal-to-noise ratio; and Phospholinked nucleotides that produce a natural DNA strand through DNA synthesis. Its product applications include de novo sequencing and resequencing. Pacific Biosciences, Inc. was formerly known as Nanofluidics, Inc.

Harlan was found in 1931 by Howard Harlan. Harlan Laboratories (formerly Harlan Sprague Dawley) is where scientists go when they need rats for the maze. Among other things, the research company produces laboratory animals and laboratory animal diets. The company is comprised of two operating groups. The Research Models group provides rodents and large animals, animal diets and bedding, and testing services to pharmaceutical and biotech companies, universities, and government agencies. The Contract Research Services division provides researchers with analytical chemistry services, toxicology services, and chemical and agrochemical registration.

Radiant Research is aglow with success. The contract research organization (CRO) conducts late phase human clinical trials for drugmakers and medical device makers at a network of some 25 research facilities that it owns across the US. Its services run the gamut from early Phase IIb trials all the way to post-approval Phase IV testing for new therapies in areas including cardiology, infectious diseases, asthma and allergies, and women's health. Radiant recruits the participants for the trials as well as gathers data for the companies; it also provides study design, consulting, and analysis services. Clients include major pharmaceutical companies, as well as biotech and medical device companies.

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