Flamel Technologies S.A. was founded in 1990 and is headquartered in Venissieux, France. Flamel Technologies S.A., a biopharmaceutical company, engages in the development of polymer-based drug delivery technologies for the improvement of medical applications in France. Its Medusa nanoparticulate technology is designed to deliver therapeutic proteins, peptides, and other large and small molecules injected subcutaneously. The company's Micropump technology is a multiparticulate technology for oral administration of small molecule drugs with applications in controlled-release, taste-masking, and bioavailability enhancement. Its products based on Medusa technology include Interferon-AlphaXL, an interferon-alpha 2b for the treatment of hepatitis C virus and various oncology applications; FT-105 basal insulin, a long-acting formulation of recombinant human insulin to insulin-dependent patients; and interleukin-2 for the treatment of renal cancer. The company's products based on Micropump technology comprise Coreg CR, an extended release formulation of carvedilol phosphate for use in the treatment of moderate to severe heart failure and left ventricular dysfunction following myocardial infarction, and hypertension; and Asacard162.5mg, a controlled release formulation of aspirin, which provide therapy for cardiovascular treatment. It has strategic alliances with GlaxoSmithKline, Merck Serono, Wyeth Pharmaceuticals, Pfizer, Corning S.A., Servier, and Corning Incorporated.

Aptuit prefers to operate behind the scenes. A pharmaceutical services company, Aptuit offers a range of support services to biotech and other drug development companies, including early- to late-stage development of pharmaceutical ingredients, clinical studies support, information systems development, project management, and consulting services. The company operates from more than a dozen offices in North America, Europe, and the Asia-Pacific region and serves companies of all sizes. Aptuit was founded in 2004; private equity firm Welsh, Carson, Anderson & Stowe holds a significant ownership stake in the company.

LEO Pharma- UK lays claim to being king of the dermatology drug jungle in the UK. LEO Pharma UK company, which is the British arm of Denmark's LEO Pharma, handles the sales and marketing LEO's dermatological and critical care pharmaceutical products in the UK. LEO Pharma UK also has a growing medical department which conducts clinical studies on behalf of the group. The parent company focuses on topical prescription medications for psoriasis and other dermatological conditions. The group's lead critical care products include anticoagulant heparin (derived from porcine mucosa) and vitamin D.

Medifacts was founded in 1985 as Core Laboratory Services and has facilities in the US, Germany, and China. Medifacts International, Inc. company specializes in cardiovascular safety data management services, including ECG (electrocardiogram) and ambulatory blood pressure monitoring services, for clients conducting pharmaceutical, biotech, and medical device development trials. It also provides data collection, consulting, training, and telemedicine services. The company has sold its Clinical Research Services division, which offered broader data management services for clinical trials.

GlaxoSmithKline plc company was founded in 1935 and is based in Brentford, the United Kingdom. GlaxoSmithKline plc, together with its subsidiaries, engages in the creation, discovery, development, manufacture, and marketing of pharmaceutical products, over the counter (OTC) medicines, and health related consumer products. The company offers prescription medicines to treat a range of conditions, such as infections, depression, skin conditions, asthma, heart and circulatory disease, and cancer. It also markets approximately 25 vaccines to prevent life-threatening or crippling illnesses, such as hepatitis A, hepatitis B, diphtheria, tetanus, whooping cough, measles, mumps, rubella, polio, typhoid, influenza, and bacterial meningitis. In addition, the company offers OTC medicines, such as alli, a weight loss medicine; Panadol, a paracetamol/acetaminophen analgesic; smoking control products under the NicoDerm, NiQuitin CQ, Nicabate, and Nicorette names; and other brands, including Breathe Right nasal strips and Tums. Its oral healthcare products primarily comprise Aquafresh, a range of toothpastes, toothbrushes, and mouthwashes; Sensodyne, a range of toothpastes and toothbrushes, including Pronamel to protect from acid erosion; Biotene, a treatment for dry mouth; and Polident, PoliGrip, and Corega, which are denture care cleansers and adhesives. Further, the company provides nutritional healthcare products, such as Lucozade, a range of energy and sports drinks; Horlicks, a range of milk-based malted food and chocolate drinks; and Ribena, a blackcurrant juice-based drink. GlaxoSmithKline operates in Europe, North America, Central and South America, the Caribbean, Asia, Australia, the Middle East, Africa, and the Southeast Asia.

International Brachytherapy (IBt) is planting the seeds of future health and vitality. IBt develops and markets interstitial implants -- commonly referred to as seeds -- used in brachytherapy to treat cancer. The radiotherapeutic implants are inserted inside or near cancerous tissue, delivering radioactive doses to tumors while sparing surrounding tissue. Founded in 1996, IBt operates from its Belgian headquarters as well as a US subsidiary, IBt Inc., and UK subsidiary IBt ltd. It also owns a majority stake in medical components provider Urorad GmbH.

EntreMed, Inc. was founded in 1991 and is headquartered in Rockville, Maryland. EntreMed, Inc. (EntreMed) is a clinical-stage pharmaceutical company focused on developing multi-mechanism oncology drugs that target disease cells and the blood vessels that nourish them. The Company focused on developing drugs that are safe and convenient, and provide the potential for improved patient outcomes. The Company has four compounds in clinical development with a pipeline of orally-active, multi-mechanism drugs for the treatment of cancer including; MKC-1, a cell cycle inhibitor, Panzem (2-methoxyestradiol or 2ME2), and ENMD-1198, an antimitotic agent. EntreMed also has active investigational new drug (IND) for its Aurora A/angiogenesis kinase inhibitor, ENMD-2076, and Panzem for rheumatoid arthritis.

XELR8 Holdings, Inc. was founded in 2000 and is based in Denver, Colorado. XELR8 Holdings, Inc. is engaged in developing, selling, marketing and distributing nutritional supplement products through a direct sales or network marketing system in which independent distributors sells the products, as well as purchase them for their own personal use. The Company also sell the products directly to the professional and Olympic athletes, and to professional sports teams. During the year ended December 31, 2008, the Company discontinued the XELR8 Snack. The products of the Company include Bazi, XELR8 EAT, XELR8 DRINK, XELR8 HYDRATE, XELR8 BUILD, and vitamins and minerals, including XELR8 SUPPORT.

Xencor, Inc. company tailors proteins, not pants. Xencor is developing therapeutics for cancer, inflammatory ailments, and autoimmune diseases. The company engineers antibodies using its Protein Design Automation (PDA) technology, which allows for the specific targeting of diseased cells. Its drug candidates aim to treat cancerous conditions such as Hodgkin's lymphoma, T-cell lymphomas, and B-cell malignancies, as well as other autoimmune diseases. Research partners include Centocor, Genentech, Eli Lilly, and Human Geonome Sciences.

Bactolac Pharmaceutical (formerly Advanced Nutraceuticals) makes private-label vitamins, minerals, herbs, and other over-the-counter nutritional supplement products. The company's encapsulated and tablet-based products are available already packaged and branded, or sold in bulk to customers who repackage them for private-label sale. Customers include distributors, retailers, and multi-level marketing companies. Its services include product formulation, sample runs, and product testing. Chairman and CEO Pailla Reddy holds a majority of the company.

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