Astellas Pharma was born after Japanese pharmaceutical firms Yamanouchi Pharmaceutical and Fujisawa Pharmaceutical Company merged in 2005, creating one of the largest pharmaceutical companies in Japan. Main products include gastritis treatment Gaster, hypertension therapy Micardis, urology treatment Vesicare, organ transplant immunosuppressant Prograf, and cholesterol drug Lipitor (sold in Japan via an agreement with Pfizer). Astellas' products (including those under development) include cardiovascular, central nervous system, oncology, diabetes, infectious disease, inflammation/immunology, gastroenterology, and urology therapies.

Agencourt Biosciences uses more modern weapons to win its battles. The company provides genomic services (including DNA and whole genome sequencing) and nucleic acid purification products that help researchers improve the effectiveness of their drug development process. The company has teamed with a handful of international distributors and marketing partners to get its products into users' hands: These partners include Affymetrix and Life Technologies (formerly Invitrogen). Agencourt Biosciences is a subsidiary of Beckman Coulter.

Upsher-Smith Laboratories, Inc. was founded in 1919 and is headquartered in Minneapolis, Minnesota with a facility in Denver, Colorado. Upsher-Smith Laboratories, Inc., a pharmaceutical company, engages in developing, manufacturing, commercializing, marketing, and distributing prescription and over-the-counter products. It offers drugs for cardiology, women's health, dermatology, neurology, and epilepsy and Parkinson's diseases. The company also provides prenatal vitamins. It serves patients, physicians, pharmacists, and healthcare organizations.

Merck OY company, a subsidiary of Germany-based Merck KGaA, manufactures, markets, and distributes prescription and over-the-counter pharmaceutical medicines. Merck OY's prescription drugs fall into targeted therapeutic categories such as diabetes, cardiovascular care, and infertility, and its consumer health care segment primarily consists of nutraceutical (vitamin) products. It also makes select chemical products, including liquid crystals and life science laboratory chemicals.

Labcyte Inc. company sells automated dispensing systems, plate assemblers, microplates, and labware supplies. Labcyte's products are built around a liquid management technology it calls Acoustic Droplet Ejection (ADE) which uses sound energy to move miniscule bits of liquid without any physical contact during transfer. ADE is useful where cross-contamination would compromise quality or data and it reduces the waste created by disposable liquid handling supplies. Labcyte's customers include pharmaceutical and biomedical research labs. The company has expanded distribution of its products into Europe and Asia.

Somaxon Pharmaceuticals is a specialty pharmaceutical company focused on the in-licensing, development and commercialization of proprietary products and late-stage product candidates for the treatment of diseases and disorders in the central nervous system therapeutic area. Our lead product candidate is Silenor® (doxepin) for the treatment of insomnia. Silenor is a sleep-specific, low-dose (3mg and 6mg), oral tablet formulation of doxepin that is patent-protected for use in insomnia. In contrast to higher-dose doxepin, Silenor is a potent antagonist that appears to selectively block histamine at the H1 receptor without a clinically relevant impact on other neurotransmitter systems. Doxepin at higher doses has been associated with a range of pharmacologic side effects that include anticholenerigic effects (dry mouth, constipation, etc.) and weight gain. In clinical trials, patients taking Silenor generally did not exhibit the side effects associated with higher doses of doxepin.

IS Pharma, formerly known as Maelor, is a UK-based drug and medical device company focused on products for the hospital market; it sells directly in the UK and uses distributors elsewhere. Among its products are Volpex, Haemopressin, and ISOplex, all critical care products used in surgery; Mysoline, an oral treatment for epilepsy; and Cryogesic and Aloxi, two cancer drugs. Maelor outlicenses some products outside its core focus areas to other firms, including its OptiFlo catheter, which is distributed by C.R. Bard. Previously limited primarily to the UK market, the firm bought Swiss drug firm Specialty European Pharma International in 2008, giving it a wider presence in Europe and in North America.

AVEO Pharmaceuticals' models don't pout, strut, or even turn heads -- unless you're a cancer drug researcher. The biotech firm develops cancer models to uncover how genes mutate into tumors and how tumors progress through additional mutations. AVEO then builds genetic profiles of such tumors and applies them to antibody (protein) drug candidates in preclinical and clinical development to help predict actual human responses. In addition to its own pipeline of potential drugs, AVEO has partnered with other pharmaceutical developers to apply its Human Response Platform to their drug candidates.

Cypress Bioscience, Inc. was founded in 1981 and is based in San Diego, California. Cypress Bioscience, Inc. provides therapeutics and personalized medicine services. The company focuses on addressing the needs of physicians and their patients by identifying unmet medical needs in the areas of pain, rheumatology, and physical medicine and rehabilitation, including challenging disorders, such as fibromyalgia and rheumatoid arthritis. It offers Savella, a dual-reuptake inhibitor that preferentially blocks the reuptake of norepinephrine for the management of fibromyalgia. The company provides personalized medicine services, which include tests that are validated analytically and clinically to provide physicians with actionable information to help manage their patients care, including predicting the likelihood of developing disease or optimizing therapy. Its personalized medicine services include Avise PG, a test that supports dose optimization and therapeutic decision making for patients taking methotrexate, a therapy for rheumatoid arthritis (RA); and Avise MCV, a test that aids in the diagnosis and prognosis of RA. The company has a license agreement with Pierre Fabre Medicament to develop and sell products with the compound milnacipran as an active ingredient for various indications in the United States and Canada; a collaboration agreement with Forest Laboratories, Inc. for the development and marketing of milnacipran; and a reformulation and new product agreement with Collegium Pharmaceutical, Inc.

Merz may be a little sterile, but it aims to take care of every part of the functioning human organism. Merz primarily makes pharmaceuticals, focusing on therapies for central nervous system and liver metabolism. The company also offers several OTC products, including cold remedies, skin care products, and vitamin supplements under the brand names tetesept and Merz Special. Subsidiaries include Merz Pharmaceuticals, Merz Consumer Care, Merz Dental, maker of dental equipment and artificial teeth, and Merz & Krell, which produces Senator-brand writing instruments.

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