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SSM Health Care System began with five nuns who fled religious persecution in Germany in 1872 only to arrive in St. Louis in the midst of a smallpox epidemic. They formed their first hospital there in 1877. Today the not-for-profit system, sponsored by the Franciscan Sisters of Mary, owns or manages 15 acute care hospitals with about 4,000 licensed beds. The company also operates physicians' practices and two nursing homes, and it offers rehabilitation, home health care, hospice, and skilled nursing services. Its facilities are located in Illinois, Missouri, Oklahoma, and Wisconsin.

St. Agnes HealthCare is here to help. St. Agnes HealthCare Catholic health system provides a spectrum of medical services to the residents of southwest Baltimore. Its flagship facility St. Agnes Hospital has about 300 beds and offers a comprehensive range of medical and surgical services, including treatment in areas such as oncology, cardiovascular disease, bariatric medicine, women's health, and orthopedics. The system also includes a multispecialty physicians group (Seton Medical Group) and a diagnostic imaging center. A member of Ascension Health, St. Agnes HealthCare has roots in the Baltimore community reaching back to 1862, when its founders, the Daughters of Charity, set up a local infirmary.

St. Anthony's Hospital offers a full array of health care services, including emergency medicine, surgery, cancer treatment, and heart care. The 400-bed hospital also provides outpatient services through two ambulatory surgery centers and an imaging center. St. Anthony's Hospital was founded in 1931 by the Sisters of the Third Order of St. Francis of Allegany. It is a member of the BayCare Health System, and as such, provides home health and occupational health services through agencies affiliated with that system.

St. Anthony's Medical Center serves St. Louis and Jefferson Counties in Missouri, as well as two southwestern Illinois counties. With about 770 beds and more than 800 affiliated physicians, the hospital provides a comprehensive offering, including inpatient and outpatient medical, surgical, diagnostic, and behavioral health care. The hospital also operates a level two trauma center, a cancer center, and a pediatric emergency center, as well as several urgent care facilities. It also offers home health, hospice, laboratory, and pharmacy services. More than 60,000 patients visit the hospital's emergency room each year. St. Anthony's Medical Center was started in 1900 by the Franciscan Sisters of Germany.

St. Bernard Hospital is a powerhouse of betterment for the people it serves. St. Bernard Hospital and Health Care Center serves the residents of Chicago's south side neighborhood of Englewood. The facility has about 200 beds, and its specialties include pediatrics, psychiatry, neurology, orthopedics, and cardiology services. St. Bernard hospital also offers inpatient detoxification services for patients dependent on opiates or alcohol. St. Bernard has a separate nonprofit unit that takes care of south side residents' residences: Bernard Place Housing Development is a 90-unit affordable homes initiative in the Englewood neighborhood.

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