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Rockwell Medical Technologies keeps on trucking with its hemodialysis products. The company (which does business as Rockwell Medical) makes hemodialysis concentrates (in liquid and dry powder form), dialysis kits, and other related products for treatment of end-stage renal disease (chronic kidney failure). Subsidiary Rockwell Transportation delivers supplies to its customers in 35 US states via its own truck fleet. The company markets and distributes its products directly to hemodialysis providers across the US, as well as through independent distributors abroad (primarily in Asia, Europe, and Latin America).

When it comes to surgical implants, RTI Biologics recommends the natural alternative. The firm develops products made from human and animal tissue that are used in orthopedic, dental, and other surgeries to repair fractures, spinal disorders, sports injuries, breast reconstruction, and other procedures. Using its BioCleanse and Tutoplast processes, the company sterilizes tissue -- including bone, tendons, and skin -- that is then used in surgeries. RTI Biologics sells its allografts (made from human tissue) and xenografts (made from animals) in the US and more than 30 countries. Its direct sales force targets the sports medicine and general orthopedic markets.

Safety Syringes wants to ensure that when you're getting needled, it's with deliberate intention. The company manufactures devices designed to prevent accidental needle pricks. Safety Syringe's products include UltraSafe Needle Guards, which attach to prefilled glass syringes, and UltraSafe Passive Needle Guards, in which a safety guard locks into place upon completion of shot delivery. The company develops products used for medical and dental drug delivery, vaccines, blood collection, and intravenous catheters. Customers for pre-filled syringes include Amgen, Merck, Roche, and Pfizer. The company was founded in 1990 and primarily operates in North America, Europe, and Asia.

Salient Surgical Technologies (formerly TissueLink Medical) tries to keep blood loss to a minimum. The company develops, manufactures, and markets medical devices using its proprietary TRANSCOLLATION, a technology that combines radiofrequency (RF) energy and saline to reduce or stop bleeding in surgery. The thermal energy is delivered via Salient's main product, AQUAMANTYS, which consists of an RF pump generator and disposable handheld sealer tools that permanently seal blood vessels, soft tissue, and bone. Salient markets the system in the US, Europe, and Asia primarily for use in orthopedic hip and knee reconstruction surgeries and certain spinal fusion procedures.

Sangui BioTech International focuses on the fluid of life -- blood. The firm specializes in developing oxygen-carrying agents to treat blocked arteries, anemia, or acute blood loss through its Sangui GmbH subsidiary. Also in the pipeline at Sangui is an implantable blood glucose monitor for diabetics. Other products include Pure Moisture, an anti-aging skin care product; HemO2Spray, a spray-on wound treatment; and Chitoskin, a wound dressing that is said to facilitate rapid healing of wounds. Professor Wolfgang K. Barnikol founded the company in Germany in 1995.

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