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Echo Therapeutics,Inc. develops instruments for transdermal (through the skin) drug delivery and diagnostics. Its devices use gentle abrasion and ultrasound technologies to painlessly extract analytes or introduce drugs without breaking the skin. The firm's proprietary Prelude SkinPrep technology platform is being developed for use in glucose monitoring under the name Symphony. Echo is also developing a system to provide needle-free drug administration of lidocaine and other pharmaceuticals. Echo is also developing Azone, a transdermal technology used for reformulated drugs already on the market.

EDAP TMS S.A. develops, manufactures, and markets non-surgical medical devices that treat urological diseases. EDAP's line of lithotripters utilize shockwaves to pulverize kidney stones. The company's Ablatherm system incorporates a technology called High Intensity Focused Ultrasound (HIFU), in which ultrasound waves are used to destroy prostate cancer cells. The company is also developing HIFU for the treatment of other types of tumors. Key subsidiaries EDAP Technomed, Inc. and EDAP Technomed Co. Ltd. market the company's products to the US and Japan, respectively. EDAP TMS was established in 1979.

Edwards, the company is a spin-off of Baxter International. Its main products are still heart valve devices, including valves made from animal tissue and annuloplasty rings that repair damaged valves. The company also makes monitoring systems that measure heart function during surgery; various types of cannulae (surgical tubes used for drainage, delivery, or filtration); and embolectomy catheters that remove blood clots from peripheral arteries. Edwards Lifesciences markets its products worldwide through a direct sales force and distributors.

Electrical Geodesics develops and sells medical equipment for use in medicine, psychology, and neuroscience research. Its EEG measurement and analysis systems are used in laboratories throughout the US, Europe, and Asia for research in areas such as neonatal sleep monitoring, stroke evaluation, dementia, and infant language comprehension. The company was founded in 1992.

Elekta AB(publ) manufactures the Gamma Knife -- which isn't a knife at all but a chamber that delivers radiation therapy to treat tumors and cancer in the brain. The Gamma Knife was invented in 1968 by Elekta's founder, Dr. Lars Leksell, the father of radiosurgery. The company manufactures other non-invasive treatment systems, such as image-guided radiation therapy (IRGT) and particle therapy, used to treat cancer elsewhere in the body. Elekta also sells health care-related software through its two subsidiaries, CMS and IMPAC. Elekta was founded in 1972. Its products are used in more than 5,000 hospitals around the world.

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