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Organogenesis has the skinny on replacement tissue. Flagship product Apligraf is a human skin substitute approved to treat diabetic foot ulcers and venous leg ulcers caused by poor circulation. Rejection-resistant Apligraf is bio-engineered using living skin cells and has been used to treat chronic open wounds in some 250,000 patients; the company is developing a next-generation version of the material (using its VCT technology) using all human components. In addition to Apligraf, Organogenesis offers a line of biomaterials used in a range of surgical procedures to seal or reconstruct soft tissue, and it also develops regenerative technologies in the area of cosmetic skin rejuvenation.

Ormco develops and distributes a variety of orthodontic equipment and supplies, including adhesives, cutting instruments, bands and crowns, brackets, trays, and wires. Its brands include Damon System, Grengloo, STb Light Lingual System, and Titanium Orthos. The company distributes its products directly and through distributors in the US and around the globe. Ormco also offers products through its online catalog. Danaher controls the company and its immediate parent firm Sybron Dental Specialties.

OrSense makes non-invasive medical monitoring equipment, based on a technology called Occlusion Spectroscopy, that measures levels of blood glucose and hemoglobin via a ring-shaped cuff, which generates a readable transmission signal when placed on the finger. Patients can self-test with OrSense's devices, which are useful for anemia screening and diabetes monitoring. Biophysicist and company CTO Ilya Fine founded OrSense in 1996 after inventing its core technology. Leading investors include STAR Ventures and Israel Health Care Ventures.

Ortho-Clinical Diagnostics earns an A+ in Chemistry. The Johnson & Johnson subsidiary develops and markets diagnostic tools, including VITROS instrumentation systems that use clinical chemistry and immunoassay technologies to diagnose a range of maladies such as cancer, heart disease, and infectious diseases. It also markets laboratory automation systems under the enGen brand. In addition to making clinical diagnostics products, Ortho-Clinical Diagnostics is a leading maker of instruments and reagents used by blood banks and hospitals to screen blood donations for disease and contaminants, as well as blood typing systems that guarantee patient-donor compatibility for transfusions.

Orthofix International N.V. makes a variety of spinal and orthopedic devices and sports medicine products used to immobilize and patch bone, as well as stimulate new growth. Its products include Firebird spinal fixation systems, Spinal-Stim bone growth stimulator, TRUE/LOK ring fixation systems for limbs, BREG Bracing limb support, and Trinity Evolution, a stem-cell based bone grafting material. The company also produces a system to improve blood flow in immobilized patients. Orthofix sells its products to healthcare providers through subsidiaries and independent distributors in Brazil, Europe, Mexico, and the US.

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