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Corin Group does its best work right at the literal crux of arthritis problems. The company designs and manufactures reconstructive orthopedic devices often used in joint replacement procedures. In addition to replacement ankles, hips, knees, and spinal implants, Corin is also working on computerized surgical systems to assist doctors during joint replacement surgery and other procedures. The company has nine subsidiaries based outside the UK, including in Austria, Japan, and Spain. Corin Group sells its products directly and through distributors in about 70 countries. The company -- which operates one main manufacturing and supply center in the UK -- was established in 1985 and went public in 2002.

CRH Medical Corporation specializes in the treatment of hemorrhoids utilizing its proprietary CRH O’Regan System which includes CRH’s patented proprietary technology and treatment protocols. CRH’s single use, disposable, hemorrhoid treatment technology is safe and highly effective in treating hemorrhoids. CRH employs two commercialization strategies: firstly, it operates Centers for Colorectal Health facilities (the “Centers”) in the United States specializing in the treatment of hemorrhoids and related anal rectal disorders. The Company currently operates ten Centers geographically dispersed through the U.S. Secondly, CRH distributes its hemorrhoid banding technology, treatment protocols, operational and marketing expertise as a complete, turn key package, directly to its partner physicians, referred to as the “Partnership Program.”

Criticare Systems helps hospitals keep better tabs on their patients. Instruments and sensors made by the company monitor the vital signs and anesthetic levels of patients undergoing surgery or confined to intensive care. Its products also provide readings for electrocardiograms and monitor oxygen saturation, carbon dioxide levels, blood pressure, temperature, heart rate, and respiration rate. Criticare's VitalView telemetry system allows one nurse to keep tabs on more than a dozen patients from a single location. The company also makes reusable pulse oximetry sensors for use with its equipment. The company is a subisidiary of India-based manufacturer Opto Circuits.

CryoCor has found that being cold-hearted can be helpful sometimes. The company makes a minimally-invasive disposable catheter and cooling console to treat common cardiac arrhythmias (heart rhythm disorders) known as atrial fibrillation and atrial flutter. Unlike commonly used heat-based cardiac ablation, its cryoablation system inserts a catheter into a blood vessel connected with the heart and uses extreme cold to destroy targeted cells and help the heart function normally. The cryoablation system is marketed for certain indications in the US and Europe. CryoCor is a part of the cardiac rhythm management division of parent Boston Scientific.

CryoLife preserves lives by conserving the tissues that sustain it. The company takes human heart valves and blood vessels from deceased volunteer donors, processes them, and stores them in liquid nitrogen freezers (a process called cryopreservation). It then ships them to surgeons nationwide, who implant them during cardiac and vascular repair procedures. For some preserved tissue, the company uses its proprietary SynerGraft technology, which reduces the presence of donor cells and makes the tissue more compatible with the recipient. CryoLife also develops implantable biomaterials, including BioGlue, an adhesive used to seal internal surgical wounds.

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