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Bonutti Technologies is on the lookout for the next big thing in medical devices. The company discovers, develops, and delivers innovative surgical and rehabilitation products. Its research and development programs focus on instruments, implants, and procedure technologies with applications in orthopedic surgery and rehabilitation therapy; successfully developed products are often spun off into independent companies. Other programs are conducted through licensing and partnership agreements with medical equipment firms such as Stryker. Bonutti Technologies markets a limited-incision total knee replacement called the L-I Approach. The company was founded by CEO Peter Bonutti.

BREG is in the business of broken bones -- and sprained ankles and wounded ACLs and all kinds of other injuries to the bones, joints, and ligaments that afflict athletes and non-athletes alike. A maker of orthopedic braces and other devices, BREG's product line includes soft goods, functional braces, and post-operative immobilizers for joints and body parts from shoulder to foot. The sports medicine company also makes devices for rehabilitation and pain management, such as home physical therapy kits and cold therapy products. BREG is a subsidiary of Orthofix International and accounts for nearly 20% of its parent's sales.

Broncus Technologies is developing and commercializing innovative solutions for diagnosing and treating lung diseases. Physicians use LungPoint® Virtual Bronchoscopic Navigation Systems to plan bronchoscopic procedures and maneuver to selected targets in the lungs accurately and quickly. The unique 18 gauge FleXNeedle™ coring needle enables peripheral sampling and access to hard-to-reach areas of the lungs. Airway Bypass is an investigational bronchoscopic procedure for emphysema patients who have shortness of breath due to lung hyperinflation.

Bruker AXS helps companies X-ray their way to the next hot drug. The firm makes X-ray systems that can analyze the structure of small molecules and aid in drug discovery and materials research. Bruker's products assist pharmaceutical and biotech firms in studying protein structure abnormalities, the cause of many diseases. Chemical and raw material manufacturers use Bruker's systems in their research of materials for making such products as steel, semiconductors, and plastics. Bruker AXS sells its products in the Asia/Pacific, Europe, and the Americas through direct sales and distributors. The company is a subsidiary of Bruker Corporation. Sister subsidiary Bruker Daltonics manufactures mass spectrometers.

BSD Medical has developed equipment to provide hyperthermia treatment, specifically for treating cancer (including melanoma, breast cancer, brain cancer, and cervical cancer) in tandem with chemotherapy and radiation therapy or as a stand-alone treatment. BSD Medical was the first to develop an approvable hyperthermia system, which uses focused radio frequencies and microwaves to heat cancer cells until they die. The company's devices are designed to target superficial tumors, as well as tumors located deep within a patient's body. Its products are sold to clinics, hospitals, and other cancer-treatment institutions through its sales force and external distributors.

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