He made his acting debut through the 2014 Telugu film Hrudaya Kaleyam.

He has earned CineMAA Award Best Actor in Comic Role for Hrudaya Kaleyam.

Sampoornesh Babu was born in Vizag, Andhra Pradesh. From childhood he has a strong desire to become a film actor in Tollywood.

Sampoornesh Babu extended his support for the victims of Cyclone Hudhud by donating 100,000 Rupees to the Chief Minister's Relief Fund.

He also took part in Memu Saitham, a fundraising event undertaken by Tollywood for the cyclone victims.

During Chennai floods, Sampoornesh Babu was the first Telugu actor to donate Rs 50,000 for relief fund.

Sampoo has a huge fan base in India as well as abroad. Sridevi from Bay Area, CA, is international fans association president, and she conducts many charitable events in sampoo's name.

Sampoornesh Babu has roped in for a new movie titled as 'Androidu'. He will be seen in three avatars in the movie and one of them will have a new hairstyle with pony on the back.

He will also be seen in an upcoming movie 'Virus', with an interesting tagline 'No Vaccine only Toxin'. It is being directed by S.R Krishna and produced by Saleem MD, Srinivas Vangala.