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Cutera has a handle on hairy situations and a firm plan for flabby faces. The firm makes lasers for medical and aesthetic use in doctors' offices and spas. Its FDA-approved devices are marketed under the names CoolGlide, Solera, and Xeo and are used for hair removal and treatments to reduce pigmented lesions (age and sun spots), wrinkles, and veins. Its Titan line of products uses deep tissue heating to firm up saggy skin. The company markets its products through a direct sales force and a distributor (PSS World Medical) in the US and relies on a small sales group and distributors in more than 30 other countries.

Cyberonics makes the first medical device to be cleared by the FDA for treating epilepsy. The company's VNS Therapy System is a pacemaker-like device implanted under the collarbone with a lead attached to the vagus nerve in the neck. The device delivers intermittent signals to the brain, dubbed vagus nerve stimulation (VNS), to control epileptic seizures. The signals can be programmed by a physician using a computer, and patients can stop or start signals with a hand-held magnet. The VNS system is also used for treatment-resistant depression, and it is being studied for conditions such as bulimia and Alzheimer's disease. In addition to the US, Cyberonics markets the system in about 70 countries around the globe.

Cynosure,Inc. makes laser and pulsed-light devices used to perform non-invasive aesthetic procedures to remove hair, treat varicose veins, remove tattoos, and reduce the appearance of birthmarks, freckles, and cellulite. Folks who want to go deeper can opt for its minimally invasive procedures to remove unwanted fat using lasers. Cynosure's systems are marketed under such names as Apogee, Cynergy, and Smartlipo. Its customers include doctors and health spas served by distributors in more than 60 countries.

D Medical develops and manufactures insulin delivery devices for patients with diabetes. Its core product, a proprietary spring-driven pump that delivers insulin and monitors insulin levels, is similar in functionality to, but differs in design from, other motor-driven pumps on the market. The company first introduced its pumps to the marketplace in 2009 when it began selling and marketing to distributors in Europe. Tracing its roots back to the early 1990s, the company became a medical device maker in 2004 after acquiring Nilimedix.

Davol keeps operating rooms in business. The company makes medical instruments and supplies for a number of surgical specialties, including hernia repair, hemostasis, laparoscopy, hysteroscopy, wound management, and orthopedics. Its hemostasis products include the Ativene brand of hemostat products used to staunch bleeding during surgery. The company also makes suction and irrigation equipment for wound care and laparoscopy, and an autotransfusion unit used in orthopedic procedures. Its hernia repair patches, plugs, grafting tissue, and fixation devices are offered under the Bard and Davol brands. Davol is a subsidiary of medical products company C.R. Bard.

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