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Merck was founded in 1668 as a pharmacy and is the oldest pharmaceutical business in the world. The Merck family owns about 70% of the company. Merck is leaving its mark on the global pharmaceutical market. Through a network of nearly 200 companies in over 60 countries, the Merck develops, makes, and sells pharmaceutical and chemical products for global consumption. Name-brand prescription drugs include treatments for cardiovascular disease, cancers, infertility, and neurological disorders; the company also makes over-the-counter pharmaceuticals. Aside from drugs, the firm makes specialty chemicals, including laboratory reagents and cosmetic ingredients, as well as liquid crystals for televisions.

Merck OY company, a subsidiary of Germany-based Merck KGaA, manufactures, markets, and distributes prescription and over-the-counter pharmaceutical medicines. Merck OY's prescription drugs fall into targeted therapeutic categories such as diabetes, cardiovascular care, and infertility, and its consumer health care segment primarily consists of nutraceutical (vitamin) products. It also makes select chemical products, including liquid crystals and life science laboratory chemicals.

Merck Sharp & Dohme is the UK subsidiary of American pharmaceutical manufacturer Merck. The company markets such Merck products as arthritis pain treatment Arcoxia (which is approved in Europe but not the US), high blood pressure medication Cozaar, osteoporosis drug Fosamax, and asthma treatment Singulair. It also operates its parent's largest manufacturing facility outside the US, making about 20 medicines at its Cramlington, Northumberland, plant. Its Hoddesdon headquarters handles sales, marketing, and administrative functions; it also includes an R&D center that runs clinical trials and performs research and development activities specializing in organic and synthetic chemistry.

Merial Limited company makes a variety of drugs and vaccines that treat and prevent disease in pets, livestock, and wildlife. Used by veterinarians, farmers, and pet owners in some 150 countries, Merial company's products include Ivomec, an anti-parasitic for livestock; Frontline flea and tick treatments for cats and dogs; heartworm prevention drug Heartgard; and rabies vaccine Raboral. Merial focuses its R&D on combating parasites, viral and bacterial invaders, and pain, as well as treating chronic conditions of household pets. Merial company is owned by Sanofi-Aventis.

Established in 2004, Merrion operates offices in North Carolina and Ireland. Merrion Pharmaceuticals wants to make complicated drug dosing regimens easier to swallow. A specialty pharmaceutical firm, Merrion develops (independently and in collaboration with other drug companies) oral drugs to replace already-approved injectable-only medicines. Using its patented drug delivery technologies, Merrion's Gastrointestinal Permeation Enhancement Technology (GIPET) improves the absorption of drugs into the blood stream. Its Gastrointestinal Retention System (GIRES) helps the stomach retain drugs, allowing for their extended, controlled release. The company has four candidates in the development pipeline.

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