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Hu-Friedy Manufacturing Company makes the tools that keep your chompers in good chomping order. In business since 1908, the company makes instruments that dentists and dental hygienists use to numb, probe, scrape, pull, and cut teeth and gums during dental visits. It also makes the Hu-Friedy Instrument Management System, an integrated system for sterilizing, storing, and organizing instruments. Its products -- many of which are hand crafted-- are used in general dentistry, as well as dental surgeries, orthodontics, and periodontics. Hu-Friedy sells its products to dental offices and dental schools both directly (in North America) and through equipment dealers worldwide.

HydroCision,Inc. founded in 1994, makes surgical tools that use a high velocity stream of water to cut, hold, and remove tissue in surgical operations. HydroCision has been focused on developing products for spinal surgeries including the SpineJet Resector and SpineJet Currette. Other clinical specialties include plastic surgery, OB/GYN, urology, and general surgery. The company also makes a surgical wound debridement (removal of dead or damaged tissue) line which is licensed and distributed by Smith & Nephew. HydroCision's investors include BioVentures, Oxford Bioscience Partners, and Triathlon Medical Ventures.

I_Flow Corporation makes mobile infusion systems used in hospitals, homes, and other settings to administer non-narcotic acute pain treatments and a variety of other drugs, including antibiotics, chemotherapies, and nutrients. I-Flow's product line includes the ON-Q branded portable infusion pumps and catheters that deliver anesthetic pain medications directly to wound sites, as well as disposable products for administration of chemotherapies and antibiotics. The company's offerings are marketed through direct sales representatives and international distributors. I-Flow is a subsidiary of Kimberly-Clark.

Imaging Diagnostic Systems is a medical technology company involved in the research and development of breast-imaging devices used for detecting cancer. Using laser-based technology, the company has created a more comfortable, radiation-free breast examination that does not require breast compression. Its CTLM (Computed Tomography Laser Mammography) system, used in conjuction with X-ray mammography, may help improve early diagnosis of cancer. The company is also researching other breast screening systems using fluorescence imaging. It had been developing laser imaging products for research with lab animals, but it has licensed the technology to Bioscan in order to focus on the women's health market.

Impres Medical is developing medical implants to help women who suffer from heavy, painful periods, a condition that affects more than 6 million women in the US. Typical treatments for the condition include hysterectomies and endometrial ablation, surgical procedures that require a lengthy recovery time. The firm's Deactivation device might one day be used by women who wish to permanently end their menstrual cycles. The treatment would be administered in the physician's office without anesthesia, with patients being able to return home the day of the procedure.

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