He was born to actor and politician Nandamuri Harikrishna and Lakshmi.

He is one of the grandsons of N. T. Rama Rao, who was an actor and a statesman.

Actor Jr.NTR is his Brother.

He is the owner of the production company named after his grandfather late NTR, called N.T.R. Arts.

Kalyan Ram started his career as an actor with Toli Choopulone (2003) produced by Ramoji Rao. His next movie was Abhimanyu (2004) produced by Ashwini Dutt.

In 2005 he established his own banner, N.T.R. Arts, under the name of his legendary grandfather NTR[4] and produced Athanokkade introducing Surender Reddy as director.

In 2015, Kalyan Ram appeared as a cop in an action entertainer titled Pataas produced under his home banner which turned out to be a blockbuster hit with positive reviews.

For the first time he produced a movie without him as the lead titled Kick 2, under his banner N.T.R. Arts. It stars Ravi Teja as a lead, and is directed by Surender Reddy, which turned out to be a flop at boxoffice.

His latest venture is titled Ism under the direction of Puri Jagannadh with Kalyan Ram playing the lead role of Reporter Balakrishna. It is being produced on N. T. R. Arts banner by Kalyan Ram like many of his previous movies.

The first look of Ism was released on 4th July on the occasion of Kalyan Ram's birthday on 5th July.