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Lorus Therapeutics isn't talking nonsense, they're talking antisense. The biotechnology firm is developing cancer drugs using antisense technology, which prevents cells from producing disease-causing proteins and may cause fewer side effects than traditional chemotherapies. It is testing its lead candidate in this area, LOR-2040, as a treatment for various blood cancers and solid tumors. Lorus is working in other areas of cancer research as well, developing some traditional therapies, as well as immunotherapies, which stimulate the body's immune system to fight cancer. The company licensed its Virulizin immunotherapy, a potential treatment for pancreatic cancer, to a subsidiary of Zoticon Bioventures in 2008.

MacroGenics Inc. company is developing therapeutic treatments for cancer, autoimmune disorders, and infectious diseases. The company is helping researchers from National Institutes of Health and two universities to develop a fully human monoclonal antibody (single disease-cell targeting protein) treatment for the deadly West Nile virus. MacroGenics is also in late development stages for another monoclonal antibody used to treat Type 1 diabetes (also known as juvenile diabetes); the diabetes treatment has received orphan drug status, an FDA designation for rare diseases. Other targeted ailments include cancer, arthritis, and multiple sclerosis.

Manhattan Pharmaceuticals, Inc. company was founded in 2001 and is based in New York, New York. Manhattan Pharmaceuticals, Inc., a development stage biopharmaceutical company, engages in the development and commercialization of pharmaceutical therapies in the United States. Its product candidates under development include Hedrin, a novel, non-insecticide treatment for pediculosis; and Topical PTH (1-34) for the treatment of psoriasis. Manhattan Pharmaceuticals has a joint venture agreement with Nordic Biotech Advisors ApS to develop and commercialize Hedrin.

MannKind Corporation was founded in 1991 and is headquartered in Valencia, California. MannKind Corporation, a biopharmaceutical company, focuses on the discovery, development, and commercialization of therapeutic products for diseases, such as diabetes and cancer. Its lead product candidate, AFRESA, a rapid-acting insulin that has completed phase 3 clinical trials for the treatment of diabetes in the United States, Europe, and Japan. The company's lead product candidates also include MKC1106-PP, which is in phase I clinical trial for the treatment of various solid-tumor cancers, including ovarian, colorectal, pancreatic, renal, breast, non-small cell lung and prostate carcinomas, glioblastoma, and melanoma.

Marker Gene Technologies sells itself. The company offers drug researchers a variety of marker genes for monitoring gene expression, intracellular targeting, and other purposes. The company's marker genes are used in research for agricultural biotechnology, cell culturing, and bacteriology. Additional products include reagents, enzyme substrates and kits, and other molecular biology products. Marker Gene Technologies also maintains four fully equipped laboratories from which it provides contract research services for biotechnology and pharmaceutical clients. The firm markets its products through a number of distributors in the US and abroad, in Europe, Asia, and the Middle East.

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